factors essential to normal blood clotting, whose absence, diminution, or excess may lead to abnormality of the clotting. Twelve factors, commonly designated by Roman numerals, have been described (I–V and VII–XIII; VI is no longer considered to have a clotting function). See terms factor I to factor XIII.
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Substances in the blood that undergo a series of chemical reactions resulting in blood coagulation (clotting).
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